發(fā)布時(shí)間：2018-05-01 16:30

  本文選題：控制釋放 + 納米醫(yī)學(xué)�。� 參考：《物理化學(xué)學(xué)報(bào)》2017年05期

【摘要】：一氧化氮(NO)是一種內(nèi)源性雙原子分子,在許多生理學(xué)和病理學(xué)過程中起了關(guān)鍵的調(diào)節(jié)作用,包括血管平滑肌松弛、免疫反應(yīng)、神經(jīng)傳遞、呼吸作用、細(xì)胞凋亡等。NO的生理調(diào)節(jié)作用在很大程度上依賴于NO釋放的位置、時(shí)間以及劑量。開發(fā)出能夠儲存NO并且在指定的地點(diǎn)和時(shí)間釋放需求量的NO的納米運(yùn)輸平臺是非常重要的研究課題。此篇綜述,主要介紹近期我們課題組和其他研究人員在NO控制釋放以及生物學(xué)應(yīng)用的研究進(jìn)展。本文首先概述了幾類具有應(yīng)用前景的外源性NO供體,如偶氮二醇烯、亞硝基硫醇、硝基苯和金屬亞硝�；�合物。然后,重點(diǎn)討論了結(jié)合NO供體和納米平臺在控制釋放NO和生物醫(yī)學(xué)的潛在應(yīng)用。
[Abstract]:Nitric oxide (no) is an endogenous diatomic molecule that plays a key role in many physiological and pathological processes, including vascular smooth muscle relaxation, immune response, neurotransmission, and respiration. The physiological regulation of no, such as apoptosis, depends to a great extent on the location, time and dose of no release. It is very important to develop a nano transport platform which can store no and release the demand of no at designated location and time. This review mainly introduces the recent progress of our research group and other researchers in the control of no release and biological applications. In this paper, several kinds of exogenous no donors, such as azodiol, nitromercaptan, nitrobenzene and metal nitrite compounds, are reviewed. Then, the potential applications of combining no donors and nanoplatforms in controlling the release of no and biomedicine were discussed.
【作者單位】： 南洋理工大學(xué)數(shù)理科學(xué)學(xué)院化學(xué)與化學(xué)生物系;華東理工大學(xué)化學(xué)與分子工程學(xué)院先進(jìn)材料教育部重點(diǎn)實(shí)驗(yàn)室;
【基金】：新加坡學(xué)術(shù)研究基金(RG112/15) 南洋理工大學(xué)-西北大學(xué)納米醫(yī)學(xué)聯(lián)合研究所及中國國家自然科學(xué)基金(21571062)資助項(xiàng)目~~
【分類號】：TB383.1
，

本文編號：1830202