發(fā)布時間：2018-07-03 00:23

  本文選題：蛋白質(zhì) + 自組裝�。� 參考：《化工進(jìn)展》2017年06期

【摘要】：膠原蛋白在體外自組裝形成高度有序的網(wǎng)狀結(jié)構(gòu),有利于細(xì)胞的黏附、增殖、擴(kuò)散和遷移,具有良好的生物相容性、優(yōu)異的力學(xué)性能、可生物降解性和弱抗原性。本文首先介紹和分析了膠原蛋白自組裝功能材料的4種組裝方法,即模板自組裝法、原位自組裝法、定向自組裝法和誘導(dǎo)自組裝法和分析的研究現(xiàn)狀;比較了4種自組裝方法的組裝原理和組裝特點(diǎn);然后總結(jié)了膠原蛋白自組裝生物功能材料作為組織替代材料,靶向給藥材料,光、電、聲特異傳導(dǎo)功能材料在再生醫(yī)學(xué)、基因治療、藥物設(shè)計、組織工程、醫(yī)學(xué)影像等領(lǐng)域的應(yīng)用現(xiàn)狀和發(fā)展趨勢;最后指出了膠原蛋白自組裝生物功能材料今后的研究方向,表明膠原蛋白自組裝生物功能材料在生物醫(yī)學(xué)領(lǐng)域具有廣闊的應(yīng)用前景。
[Abstract]:Collagen is self-assembled in vitro to form a highly ordered reticular structure, which is conducive to cell adhesion, proliferation, diffusion and migration, with good biocompatibility, excellent mechanical properties, biodegradability and weak antigenicity. In this paper, four kinds of assembly methods of collagen self-assembly functional materials, I. E. template self-assembly, in-situ self-assembly, directed self-assembly and induced self-assembly, are introduced and analyzed. The principles and characteristics of the four self-assembly methods were compared, and then the biological functional materials of collagen self-assembly were summarized as tissue substitute materials, targeted drug delivery materials, optical, electrical and acoustic specific conduction functional materials in regenerative medicine. The application and development trend of gene therapy, drug design, tissue engineering, medical imaging, etc. Finally, the future research direction of collagen self-assembly biological functional materials is pointed out. It shows that collagen self-assembly biological functional materials have a broad application prospect in biomedical field.
【作者單位】： 陜西科技大學(xué)輕工科學(xué)與工程學(xué)院中國輕工業(yè)皮革清潔生產(chǎn)重點(diǎn)實(shí)驗(yàn)室;青海師范大學(xué)化學(xué)化工學(xué)院;
【分類號】：R318.08
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本文編號：2091540