發(fā)布時(shí)間：2018-07-04 21:47

  本文選題：d-f聚合物 + 金納米籠　； 參考：《上海師范大學(xué)》2017年碩士論文

【摘要】：傳統(tǒng)的d-f配合物納米粒子由于良好的光學(xué)-磁學(xué)性質(zhì),在光學(xué)成像,磁共振成像,磁共振成像與光動(dòng)力學(xué)治療等方面得到了廣泛的應(yīng)用。但由于d-f配合物納米粒子的吸收主要在紫外-可見(jiàn)光區(qū),限制了其在活體層次的應(yīng)用。金納米籠是一類(lèi)出色的光熱轉(zhuǎn)換材料,對(duì)近紅外光有很強(qiáng)的吸收能力,可以用于光聲成像與光熱治療等。本文提出了一種結(jié)合的策略——將銥-鏑配位聚合物包裹在金納米籠表面,得到了d-f配合物雜化的金納米籠(AuNC@CPs),并對(duì)AuNC@CPs的性質(zhì)進(jìn)行了研究。本文的主要內(nèi)容包括:(1)通過(guò)多元醇還原的方法合成了銀納米立方塊,并以銀納米立方塊為原料,合成了一系列不同的金納米籠,并對(duì)金納米籠形成機(jī)理及其光譜性質(zhì)進(jìn)行了討論;(2)以局部表面等離子體共振(LSPR)峰在697 nm的金納米籠為模板,用HS-PEG-NH2進(jìn)行表面修飾,最后采用透析法將配位聚合物與金納米籠進(jìn)行雜化,得到具有核殼結(jié)構(gòu)的AuNC@CPs,并且產(chǎn)物的LSPR峰紅移到了825 nm。我們對(duì)AuNC@CPs的合成機(jī)理與方法的普適性進(jìn)行了討論;(3)利用AuNC@CPs的近紅外吸收性質(zhì),磷光發(fā)射性質(zhì)與磁性,在溶液層次進(jìn)行了AuNC@CPs的光熱,光動(dòng)力學(xué),光聲成像與磁共振成像研究;(4)在細(xì)胞與活體層次,對(duì)AuNC@CPs的光學(xué)成像,光熱治療,光聲成像與磁共振成像進(jìn)行了研究。
[Abstract]:The traditional d-f complex nanoparticles have been widely used in optical imaging, magnetic resonance imaging and photodynamic therapy due to their good optical and magnetic properties. However, the absorption of d-f complex nanoparticles is mainly in the UV-Vis region, which limits their application at the in vivo level. Gold nanocage is a kind of excellent photothermal conversion material. It has strong absorption ability to near infrared light and can be used in photoacoustic imaging and photothermal therapy. In this paper, a binding strategy is proposed, in which iridium dysprosium coordination polymer is encapsulated on the surface of gold nanospheres, and the au cages (AuNCfollow-up CPs) hybrid with d-f complexes are obtained, and the properties of AuNCfollow-up CPs are studied. The main contents of this paper are as follows: (1) Silver nanorods were synthesized by polyol reduction, and a series of different gold nanometers were synthesized from silver nanorods. The formation mechanism and spectral properties of gold nanorages were discussed. (2) the gold nanocages with local surface plasmon resonance (LSPR) peak at 697 nm were used as templates and HS-PEG-NH2 was used to modify the surface. Finally, the coordination polymer was hybridized with gold nanocapron by dialysis method, and AuNCBP with core-shell structure was obtained, and the LSPR peak of the product was shifted to 825 nm. We have discussed the synthesis mechanism and the universality of the method of AuNC@ CPs. (3) the photothermal and photodynamic properties of AuNCneuroCPs have been carried out at the solution level using the near infrared absorption, phosphorescence and magnetism of AuNC@ CPs. (4) the optical imaging, photothermal therapy, photoacoustic imaging and magnetic resonance imaging of AuNCCCPs were studied at the cellular and in vivo levels.
【學(xué)位授予單位】：上海師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R318;O641.4

【參考文獻(xiàn)】

相關(guān)碩士學(xué)位論文 前1條

1 張紅衛(wèi);d-f金屬配合物納米粒子以及普魯士藍(lán)修飾的Fe_3O_4納米粒子在診療一體化中的研究[D];上海師范大學(xué);2016年

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本文編號(hào)：2097573