發(fā)布時間：2018-06-03 18:10

  本文選題：精神分裂癥 + 慢性乙型病毒性肝炎��； 參考：《中國新藥雜志》2017年01期

【摘要】：目的:比較奧氮平和利培酮治療精神分裂癥合并慢性乙型病毒性肝炎(慢性乙肝)患者的療效及其對糖脂代謝的影響。方法:將合并慢性乙肝的65例精神分裂癥患者分為奧氮平組(n=32)和利培酮組(n=33),治療8周。在治療前及治療后8周末采用陽性與陰性癥狀量表(PANSS)進行評分,評定療效;比較2組治療前后血糖、血脂變化和體質量改變。結果:奧氮平組和利培酮組治療8周后PANSS減分率分別為65.6%和66.7%,差異無統(tǒng)計學意義(P0.05)。奧氮平組患者治療后體質量指數(shù)(BMI)、空腹血糖、甘油三酯、總膽固醇和低密度脂蛋白升高。利培酮組患者治療后空腹血糖、總膽固醇升高,但幅度低于奧氮平組。結論:利培酮治療合并慢性乙肝的精神分裂癥患者的療效與奧氮平相當,但對糖脂代謝和BMI影響較小,較適于合并慢性乙肝精神分裂癥患者的治療。
[Abstract]:Aim: to compare the efficacy of olanzapine and risperidone in the treatment of schizophrenia with chronic hepatitis B (CHB) and its effect on glucose and lipid metabolism. Methods: 65 schizophrenic patients with chronic hepatitis B were divided into olanzapine group (n = 32) and risperidone group (n = 33) for 8 weeks. Positive and negative symptom scale (PANSS) was used to evaluate the efficacy before and after treatment, and the changes of blood glucose, blood lipid and body mass were compared before and after treatment. Results: the PANSS reduction rates of olanzapine group and risperidone group were 65.6% and 66.7% respectively after 8 weeks of treatment with no significant difference (P 0.05). In the olanzapine group, body mass index (BMI), fasting blood glucose, triglyceride, total cholesterol and low density lipoprotein increased after treatment. The fasting blood glucose and total cholesterol in risperidone group were higher than those in olanzapine group. Conclusion: the efficacy of risperidone in the treatment of schizophrenia with chronic hepatitis B is similar to that of olanzapine, but has little effect on glucose and lipid metabolism and BMI, so it is more suitable for the treatment of patients with chronic hepatitis B schizophrenia.
【作者單位】： 北京回龍觀醫(yī)院心身醫(yī)學科;
【基金】：北京市自然科學基金青年項目(7154208)
【分類號】：R749.3;R512.62

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