發(fā)布時(shí)間：2018-07-10 09:41

  本文選題：生物醫(yī)學(xué)光子學(xué) + 光學(xué)系統(tǒng)　； 參考：《光子學(xué)報(bào)》2017年08期

【摘要】：針對(duì)具有復(fù)雜形貌的大面積組織體,基于空間頻率域方法,提出并搭建了一種具有在線形貌矯正能力的絕對(duì)光學(xué)參數(shù)測(cè)量系統(tǒng).首先利用相位輪廓術(shù)獲取組織體三維表面輪廓,用余弦輻射公式法矯正由組織體表面復(fù)雜形貌引起的光照度的差異.然后,采用漫反射板代替?zhèn)鹘y(tǒng)方法中的參考仿體,基于空間頻率域測(cè)量模式進(jìn)行絕對(duì)光學(xué)參數(shù)測(cè)量,并利用提出的光學(xué)參數(shù)反演方法實(shí)現(xiàn)組織體吸收系數(shù)的重建.組織仿體實(shí)驗(yàn)結(jié)果表明,對(duì)于表面高度小于29mm的仿體,經(jīng)矯正后,吸收系數(shù)的測(cè)量相對(duì)誤差從60%下降到13%.
[Abstract]:Based on the spatial frequency domain method, an absolute optical parameter measurement system with the ability of on-line morphology correction is proposed for large area tissue with complex morphology. Firstly, the three-dimensional surface profile of tissue was obtained by phase profilometry, and the difference of illumination caused by complex topography of tissue surface was corrected by cosine radiation formula. Then, the diffuse reflectance plate is used to replace the reference object in the traditional method, and the absolute optical parameters are measured based on the spatial frequency domain measurement mode. The proposed optical parameter inversion method is used to reconstruct the absorption coefficient of the tissue volume. The results showed that the relative error of absorption coefficient was decreased from 60% to 13% when the surface height of the imitating body was less than that of 29mm, and the relative error of absorption coefficient was decreased from 60% to 13% after correction.
【作者單位】： 天津大學(xué)精密儀器與光電子工程學(xué)院;天津市生物醫(yī)學(xué)檢測(cè)技術(shù)與儀器重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金(Nos.61475116,81371602,61475115,81401453,61575140,81571723) 天津市自然科學(xué)基金(No.15JCZDJC31800)資助~~
【分類(lèi)號(hào)】：R312

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