發(fā)布時(shí)間：2018-02-23 02:54

  本文關(guān)鍵詞： 戊型肝炎病毒抗體 人乳頭狀瘤病毒抗體 酶鏈免疫吸附試驗(yàn) 危險(xiǎn)因素　出處：《重慶醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的： 1.調(diào)查目標(biāo)地區(qū)女性人乳頭瘤病毒抗體（HPV L1-IgG）與戊型肝炎病毒抗體（HEV-IgG）分布情況與危險(xiǎn)因素。 2.初步評(píng)價(jià)HEV疫苗作為HPV疫苗對(duì)照的可行性。 方法： 研究對(duì)象為低成本子宮頸癌分子技術(shù)篩查方法項(xiàng)目人群，基線時(shí)使用HPV/VIA/VILI篩查，上述檢測(cè)任一陽(yáng)性和10%陰性召回進(jìn)行陰道鏡檢查的婦女，以及10%陰性沒有召回陰道鏡檢查的婦女，合計(jì)952例。收集靜脈血檢測(cè)HPV與HEV相關(guān)抗體，了解該人群HPV與HEV抗體的分布情況與相關(guān)程度。 通過(guò)調(diào)查問(wèn)卷收集該人群的一般人口學(xué)特征和可能的危險(xiǎn)因素信息，用χ2檢驗(yàn)進(jìn)行單因素分析，有統(tǒng)計(jì)學(xué)意義的因素再進(jìn)一步行多因素Logistic回歸分析，以分析HPV與HEV抗體的危險(xiǎn)因素，并同時(shí)比較兩種抗體之間是否存在相同的危險(xiǎn)因素。 結(jié)果： 研究人群的平均年齡為47.2歲，平均工齡24.0年，年收入均數(shù)為5210.2元，農(nóng)民比例為85.8%，低收入人群比例為44.5%。952名研究對(duì)象中，HPV L1-IgG陽(yáng)性率為26.8%，HEV-IgG陽(yáng)性率為30.9%，HPVL1-IgG與HEV-IgG的表達(dá)水平基本隨年齡增長(zhǎng)而升高，且有統(tǒng)計(jì)學(xué)意義（P＜0.05）。HPV L1-IgG與HEV-IgG的表達(dá)相互獨(dú)立（Kappa=-0.010，P=0.749），在HPV L1-IgG與HEV-IgG抗體陽(yáng)性組與陰性組中，年齡與初次性生活年齡的分布差異有統(tǒng)計(jì)學(xué)意義（P0.05）。 單因素分析結(jié)果顯示：工作年限(以30年為界)，初潮年齡（以13歲為界），有無(wú)接受教育在HPV L1-IgG陰陽(yáng)性組中分布差異有統(tǒng)計(jì)學(xué)意義（P0.05）；工作年限(以30年為界)，低收入人群，有無(wú)接受教育在HEV-IgG陰陽(yáng)性組中分布差異有統(tǒng)計(jì)學(xué)意義（P0.05）。多因素分析結(jié)果顯示：年齡[OR=1.022，95%CI(1.001-1.043)]、初次性生活年齡[OR=0.923，95%CI(0.861-0.990)]、是否接受過(guò)教育[OR=1.587，95%CI(1.065-2.365)]為HPV L1-IgG陽(yáng)性的影響因素；年齡[OR=1.050，95%CI(1.031-1.069)]、是否為低收入人群[OR=1.341，95%CI(1.004-1.790)]、是否為農(nóng)民[OR=0.604，95%CI(0.402-0.906)]為HEV-IgG陽(yáng)性的影響因素。 結(jié)論： 1.新密地區(qū)女性人群HEV-IgG的陽(yáng)性率高于以往研究，并隨年齡增長(zhǎng)而升高。 2. HEV-IgG與HPV L1-IgG的抗體未見相關(guān)性；年齡是HEV-IgG與HPV L1-IgG抗體的共同危險(xiǎn)因素；HEV-IgG與HPV L1-IgG抗體無(wú)其他共同危險(xiǎn)因素。
[Abstract]:Objective:. 1. To investigate the distribution and risk factors of HPV-L1-IgG and HEV-IgG in the target areas. 2. To evaluate the feasibility of HEV vaccine as HPV vaccine control. Methods:. The subjects of the study were a group of low-cost molecular screening methods for cervical cancer using HPV/VIA/VILI screening at baseline, and any of the above positive and 10% negative women recalled for colposcopy. And 10% negative women who did not recall colposcopy, totally 952 cases, collected venous blood to detect HPV and HEV related antibodies, to understand the distribution and correlation of HPV and HEV antibodies in this population. The general demographic characteristics and possible risk factors of the population were collected by questionnaire, and univariate analysis was carried out with 蠂 2 test. The statistically significant factors were further analyzed by multivariate Logistic regression analysis. To analyze the risk factors of HPV and HEV antibodies, and to compare whether the same risk factors exist between the two antibodies. Results:. The average age was 47.2 years, the average working life was 24.0 years, and the average annual income was 5210.2 yuan. The proportion of farmers was 85.8 and the proportion of low-income population was 44.5. 952 subjects. The positive rate of HPVL1-IgG was 26.8HPVL1-IgG. The positive rate of HPVL1-IgG and HEV-IgG increased with age. The expression of HPVL1-IgG and HPVL1-IgG was independent of HPV L1-IgG and HEV-IgG. The distribution of age and age of first sexual life was significantly different between the positive group of HPV L1-IgG and HEV-IgG antibody and the negative group (P 0.05). The results of univariate analysis showed that there were significant differences in the number of years of work (30 years as boundary, menarche age (13 years of age), and the distribution of education in HPV L1-IgG negative and positive group (P 0.05), working life (30 years as boundary, low income group). The results of multivariate analysis showed that age [OR1. 022 + 95 CIQ 1.001-1.043], first sexual life age [OR0.923 + 95CII 0.861-0.990], education [OR1.58795CI1.065-2.365] were the influential factors of HPV L1-IgG positive. Age [ORX 1.050 + 95 CI 1.031-1.069], low income group (OR1.341CII 1.004-1.790), farmers [ORO0.60495CII 0.402-0.906] were influential factors of HEV-IgG positive. Conclusion:. 1. The positive rate of HEV-IgG in female population in Xinmi area was higher than that in previous studies and increased with age. 2. There was no correlation between HEV-IgG and HPV L1-IgG antibody, age was the common risk factor of HEV-IgG and HPV L1-IgG antibody. There was no other common risk factor between HEV-IgG and HPV L1-IgG antibody.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R512.6

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