發(fā)布時(shí)間：2018-01-30 04:55

  本文關(guān)鍵詞： 右美托咪定 羅哌卡因 肋間神經(jīng) 神經(jīng)阻滯 乳腺癌 術(shù)后鎮(zhèn)痛　出處：《廣東醫(yī)學(xué)》2017年03期 　論文類型：期刊論文

【摘要】：目的觀察右美托咪定復(fù)合羅哌卡因肋間神經(jīng)阻滯在乳腺癌術(shù)后鎮(zhèn)痛的應(yīng)用。方法 40例患者隨機(jī)分為RD組和R組(n=20),RD組肋間神經(jīng)阻滯用0.375%羅哌卡因20 m L復(fù)合右美托咪定1μg/kg;R組用0.375%羅哌卡因20 m L。記錄術(shù)后0、0.5、1、2、4、8 h血流動力學(xué)變化;觀察神經(jīng)阻滯起效時(shí)間、鎮(zhèn)痛持續(xù)時(shí)間及術(shù)后首次VAS評分,并記錄不良反應(yīng)。結(jié)果與R組相比,RD組患者注藥后0.5、1、2、4 h心率減慢,差異有統(tǒng)計(jì)學(xué)意義(P0.05),羅哌卡因起效時(shí)間縮短,鎮(zhèn)痛時(shí)間明顯延長,首次VAS評分降低(P0.05),且口干發(fā)生率高。結(jié)論右美托咪定1μg/kg復(fù)合0.375%羅哌卡因20 m L肋間神經(jīng)阻滯可以有效用于乳腺癌術(shù)后鎮(zhèn)痛。
[Abstract]:Objective to observe the application of dexmetomidine combined with ropivacaine intercostal nerve block in postoperative analgesia of breast cancer. Methods Forty patients were randomly divided into Rd group and R group. In Rd group, 0.375% ropivacaine 20 mL combined with dexmetomidine 1 渭 g / kg was used for intercostal nerve block. Group R was treated with 0.375% ropivacaine (20 mL). The onset time of nerve block, the duration of analgesia and the first VAS score after operation were observed, and the adverse reactions were recorded. Results compared with R group, the heart rate of Rd group was significantly slower than that of R group. The difference was statistically significant (P 0.05). The onset time of ropivacaine was shortened, the analgesia time was significantly prolonged, and the first VAS score was decreased (P 0.05). Conclusion 1 渭 g / kg dexmetomidine combined with 0.375% ropivacaine 20 mL intercostal nerve block can be used for postoperative analgesia of breast cancer.
【作者單位】： 淮安市婦幼保健院麻醉科;
【分類號】：R614;R737.9
【正文快照】： 乳腺癌術(shù)后由于切口長、敷料對傷口壓迫、患者緊張焦慮等因素常需要術(shù)后鎮(zhèn)痛,靜脈鎮(zhèn)痛常導(dǎo)致惡心嘔吐等不良反應(yīng),因此選擇合適的鎮(zhèn)痛方法和藥物很重要。右美托咪定(dexmedetomidine,Dex)是一種高選擇性α2受體激動劑,具有鎮(zhèn)靜鎮(zhèn)痛雙重功能,將其復(fù)合羅哌卡因用于臂叢神經(jīng)阻滯,

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