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  本文關(guān)鍵詞： 乳腺非特殊型浸潤性癌 臨床特征 淋巴管瘤栓分級 預(yù)后　出處：《河北醫(yī)科大學(xué)》2017年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討乳腺非特殊型浸潤性癌(Invasive carcinomas of no special type,ICNST)的淋巴管瘤栓分級與預(yù)后相關(guān)性分析。方法:回顧性分析河北醫(yī)科大學(xué)第四醫(yī)院2006年1月-2008年12月確診的ICNST患者共466例,整理患者的臨床病理資料,并進行D2-40、ER、PR和HER2免疫組化染色,確定腫物淋巴管瘤栓及個數(shù),并按照每高倍視野瘤栓核分裂及凋亡細胞數(shù)進行分級。電話隨訪患者的生存時間,采用spearman檢驗進行相關(guān)分析,Kaplan-Meier曲線描述患者生存率,Log-rank檢驗及Cox風險回歸模型進行生存時間影響因素分析。結(jié)果:466例ICNST患者中,淋巴管瘤栓0級280例(60.09%),1級112例(24.03%),2級58例(12.45%),3級16例(3.43%)。相關(guān)分析結(jié)果表明:淋巴管瘤栓分級與淋巴結(jié)轉(zhuǎn)移個數(shù)呈正相關(guān)(P0.001);單因素生存分析顯示:ICNST患者組織學(xué)分級、淋巴管瘤栓分級、淋巴結(jié)轉(zhuǎn)移個數(shù)、ER、PR、HER2表達及分子分型與ICNST患者生存時間相關(guān)(P0.05)。Cox比例風險模型多因素分析顯示,淋巴管瘤栓分級及淋巴結(jié)轉(zhuǎn)移個數(shù)情況是影響ICNST患者生存時間的獨立預(yù)后因素(P0.05)。結(jié)論:ICNST患者的淋巴管瘤栓分級及淋巴結(jié)轉(zhuǎn)移個數(shù)情況可預(yù)測其預(yù)后,提示病理醫(yī)師要對這一特征予以關(guān)注。
[Abstract]:Objective: to investigate the invasive carcinomas of no special type in breast. ICNST). Methods: a total of 466 patients with ICNST diagnosed from January 2006 to December 2008 in 4th Hospital of Hebei Medical University were retrospectively analyzed. The clinicopathological data of the patients were collected and the number and number of lymphangioma embolus were determined by immunohistochemical staining of D2-40 ERN PR and HER2. According to the number of mitotic and apoptotic cells per high-power field tumor thrombus, the survival time of the patients was followed up by telephone, and the correlation analysis was carried out by spearman test. The survival rate was described by Kaplan-Meier curve. Log-rank test and Cox risk regression model were used to analyze the factors affecting survival time. Results among 466 patients with ICNST, 280 cases had lymphangioma thrombus grade 0 (60.09%). Grade 1, 112 cases (24.03) and grade 2 (58 cases, 12.45). The results of correlation analysis showed that the classification of lymphangioma thrombus was positively correlated with the number of lymph node metastasis (P 0.001). Univariate survival analysis showed histological grade, lymphangioma thrombus grade, lymph node metastasis and ERPR in the patients with ICNST. HER2 expression and molecular typing were correlated with survival time of ICNST patients. The classification of lymphangioma thrombus and the number of lymph node metastases were independent prognostic factors influencing the survival time of ICNST patients (P0.05). Conclusion the classification of lymphangioma thrombus and the number of lymph node metastases in patients with ICNST can predict the prognosis. It suggests that pathologists should pay attention to this feature.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R737.9

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