發(fā)布時間：2024-06-15 03:12

　　目的:基于2016版WHO中樞神經(jīng)系統(tǒng)腫瘤分類,應用常規(guī)MRI紋理分析鑒別Ⅱ、Ⅲ、Ⅳ級腦膠質(zhì)瘤以及其基因突變情況,探討紋理參數(shù)與病理-基因變化的相關性,從而明確紋理分析是否可以常規(guī)應用于腦膠質(zhì)瘤的無創(chuàng)性診斷和治療計劃中。材料和方法:回顧性研究51例腦膠質(zhì)瘤患者(女27例,男24例):其中15例WHOⅡ型膠質(zhì)瘤,19例WHOⅢ型膠質(zhì)瘤,17例WHOⅣ型膠質(zhì)瘤。術前使用1.5T MRI((Signa HDxt,General Electronic Co,Milwaukee,WI,USA)進行軸位T1WI、T2WI和T1WI增強序列掃描,在ADW4.6工作站生成DICOM格式圖像。使用omnikinetics軟件(GE Healthcare,CHINA)進行紋理分析(MR texture analysis,MRTA),在T1WI、T2WI、T1WI增強的每層圖像上沿腫瘤全域的邊緣手動描繪ROI,然后將所有層面的ROI累加為一個3D ROI。本研究分為五組:第一組根據(jù)腫瘤的等級(WHO II-III-IV)確定;其他四組根據(jù)特定基因(P53,IDH-1,GFAP,EGFR)確定,每組分別對比基...

【文章頁數(shù)】：61 頁

【學位級別】：碩士

【文章目錄】：
Abstract
摘要
1 INTRODUCTION
2 MATERIELS AND METHODS
    2.1 Study Population
    2.2 MRI Protocols
    2.3 Image features and analysis
    2.4 Statistical analysis
3 RESULTS
    3.1 Clinical and genetic data
    3.2 MRTA comparison between grades II, III and IV
    3.3 MRTA of gliomas with P53 mutation
    3.4 MRTA of gliomas with IDH-1 mutation
    3.5 MRTA of gliomas with GFAP-mutation
    3.6 MRTA of gliomas with EGFR-mutation
    3.7 Correlation of MRTA parameters with percentage of Ki-67
4.DISCUSSION
5.LIMITATIONS
6.CONCLUSION
REFERENCES
Literature Review
    1 INTRODUCTION
    2 TEXTURE ANALYSIS
    3 CEREBRAL GLIOMAS
        3.1 GENETICS
        3.2 SYMPTOMS
        3.3 SPECIFIC FEATURES
            3.3.1 Low Grade Diffuse Astrocytoma (WHO II) [24,25,26,27]
            3.3.2 Anaplastic Astrocytoma (WHO III) [9,7, ,6,]
            3.3.3 Oligodendroglioma (WHO II)[33,34,35]
            3.3.4 Anaplastic Oligodendroglioma (WHO III) [45,46,35]
            3.3.5 Oligoastrocytoma:
            3.3.6 Glioblastoma (WHO IV) [48,49]
        3.4 TREATMENT
    4 MRI TEXTURE ANALYSIS OF CEREBRAL GLIOMAS
    5 CONCLUSIONS
    REFERENCES
附件
Acknowledges



本文編號：3994837