發(fā)布時間：2018-08-17 12:57

【摘要】：目的:評價平均血小板體積(MPV)對急性ST段抬高型心肌梗死(STEMI)患者預(yù)后的影響。方法:連續(xù)入選2010-01-01至2014-10-31于我院住院確診為STEMI并接受經(jīng)皮冠狀動脈介入治療(PCI)的1 012例患者,于2015-10進(jìn)行隨訪,記錄主要不良心血管事件(MACE)。基于受試者工作特征(ROC)曲線確定的全因死亡的MPV最佳界值,將患者分為低MPV組和高M(jìn)PV組。比較兩組患者M(jìn)ACE發(fā)生率,并用單因素及多因素COX回歸分析MPV對接受PCI治療的STEMI患者預(yù)后的影響。結(jié)果:ROC曲線確定的全因死亡的MPV最佳界值為9.466 fl,低MPV組549例(MPV≤9.466 fl)和高M(jìn)PV組463例(MPV9.466 fl)。隨訪時間為34(12~69)個月。與低MPV組比,高M(jìn)PV組患者PCI后具有更高的全因死亡(P0.001)及心原性死亡發(fā)生率(P=0.001)。多因素校正后,COX回歸分析仍顯示入院高M(jìn)PV為接受PCI的STEMI患者全因死亡(HR=1.463,P0.001)及心原性死亡(HR=1.458,P0.001)事件的獨立危險因素。結(jié)論:入院MPV增高對PCI后STEMI患者的長期預(yù)后有預(yù)測價值。
[Abstract]:Objective: to evaluate the effect of mean platelet volume (MPV) on the prognosis of patients with acute St segment elevation myocardial infarction (St segment elevation myocardial infarction) (STEMI). Methods: a total of 1,012 consecutive patients who were admitted to our hospital from 2010-01-01 to 2014-10-31 to receive percutaneous coronary intervention (PCI) were enrolled and followed up in 2015-10 to record major adverse cardiovascular events (MACE). Patients were divided into two groups: low MPV group and high MPV group based on the optimal MPV threshold of all-cause death determined by operating characteristic (ROC) curve. The incidence of MACE was compared between the two groups, and the influence of univariate and multivariate COX regression analysis (MPV) on the prognosis of STEMI patients treated with PCI was analyzed. Results the optimal limit of MPV for all-cause death was 9.466 fll, 549cases in low MPV group (MPV 鈮，

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