Wip1相關(guān)研究進(jìn)展
發(fā)布時(shí)間:2018-08-26 07:43
【摘要】:正Fiscella等~([1])首次通過γ射線或UV射線誘導(dǎo)發(fā)現(xiàn)了野生型p53誘導(dǎo)的磷酸酶1(wild-type p53-induced phosphatase 1,Wip1),并且證實(shí)Wip1的表達(dá)依賴于p53。編碼Wip1蛋白的基因稱為PPM1D,定位于人染色體17q23和小鼠第11號(hào)染色體上,PPM1D編碼的mRNA在很多器官組織包括睪丸和
[Abstract]:The wild-type p53 induced phosphatase 1 (wild-type p53-induced phosphatase 1 + Wip1) was first discovered by positive Fiscella et al ~ ([1]) by 緯-ray or UV-ray induction, and the expression of Wip1 was confirmed to be dependent on p53. The gene that encodes Wip1 protein, called PPM1D, is located on human chromosome 17q23 and on mouse chromosome 11, where PPM1D encodes mRNA in many organs, including testis and testes.
【作者單位】: 國家心血管病中心 中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 北京協(xié)和醫(yī)學(xué)院;
【基金】:國家自然科學(xué)基金資助項(xiàng)目(No.81270288;No.81541095)
【分類號(hào)】:R54
本文編號(hào):2204191
[Abstract]:The wild-type p53 induced phosphatase 1 (wild-type p53-induced phosphatase 1 + Wip1) was first discovered by positive Fiscella et al ~ ([1]) by 緯-ray or UV-ray induction, and the expression of Wip1 was confirmed to be dependent on p53. The gene that encodes Wip1 protein, called PPM1D, is located on human chromosome 17q23 and on mouse chromosome 11, where PPM1D encodes mRNA in many organs, including testis and testes.
【作者單位】: 國家心血管病中心 中國醫(yī)學(xué)科學(xué)院阜外醫(yī)院 北京協(xié)和醫(yī)學(xué)院;
【基金】:國家自然科學(xué)基金資助項(xiàng)目(No.81270288;No.81541095)
【分類號(hào)】:R54
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