細胞內(nèi)蛋白質(zhì)降解：通過溶酶體和泛素——蛋白酶體系統(tǒng)探索人類疾病和藥物靶向治療的未來（英文）
發(fā)布時間：2024-06-13 21:34
在真核細胞內(nèi)主要存在兩種蛋白降解系統(tǒng),自噬—溶酶體系統(tǒng)和泛素—蛋白酶體系統(tǒng)(UPS),對維持蛋白穩(wěn)態(tài)至關重要。本文綜述了自噬—溶酶體系統(tǒng)和UPS的組成、功能、相互作用、功能相關性以及與腫瘤的關系,其作為藥物靶標的可行性,對于未來腫瘤靶向藥物的研制具有重要的指導作用,同時對于全面理解自噬—溶酶體系統(tǒng)和UPS的功能和機制也有重要的參考價值。
【文章頁數(shù)】：17 頁
【文章目錄】：
1 Introduction
2 Introduction to eukaryotic protein deg-radation system
3 Ubiquitin as the core of UPS and au-tophagy
4 Ubiquitin-based proteasome
5 Ubiquitin-based autophagy degradation
6 Antagonism and interaction between 6UPS and autophagy
6.1 Interference from UPS to autophagy
6.2 Interference from autophagy to UPS
6.3 Interplay between autophagy and UPS
6.4 UPS and autophagy interaction
6.5 Interaction between autophagy and UPS through the domain
7 Autophagy and cancer
8 UPS and cancer
9 DUB and cancer
1 0 DUB and autophagy simultaneous positioning
1 1 Human diseases and drug targeted therapy
1 2 Conclusions and prospects
本文編號：3993672
【文章頁數(shù)】：17 頁
【文章目錄】：
1 Introduction
2 Introduction to eukaryotic protein deg-radation system
3 Ubiquitin as the core of UPS and au-tophagy
4 Ubiquitin-based proteasome
5 Ubiquitin-based autophagy degradation
6 Antagonism and interaction between 6UPS and autophagy
6.1 Interference from UPS to autophagy
6.2 Interference from autophagy to UPS
6.3 Interplay between autophagy and UPS
6.4 UPS and autophagy interaction
6.5 Interaction between autophagy and UPS through the domain
7 Autophagy and cancer
8 UPS and cancer
9 DUB and cancer
1 0 DUB and autophagy simultaneous positioning
1 1 Human diseases and drug targeted therapy
1 2 Conclusions and prospects
本文編號：3993672
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