a国产,中文字幕久久波多野结衣AV,欧美粗大猛烈老熟妇,女人av天堂

當前位置:主頁 > 醫(yī)學論文 > 病理論文 >

一氧化氮在高壓氧誘導低氧耐受中的作用

發(fā)布時間:2018-02-27 06:06

  本文關(guān)鍵詞: 高壓氧 低氧 低氧耐受 一氧化氮 一氧化氮合酶 出處:《第二軍醫(yī)大學》2006年碩士論文 論文類型:學位論文


【摘要】:低氧是多種疾病如心、肺疾病、中風及腫瘤的主要病理生理反應(yīng)。經(jīng)典的誘導低氧耐受的方法為低氧預(yù)適應(yīng)。大量研究表明,高壓氧(hyperbaric oxygen,HBO)和低氧適應(yīng)性暴露都可增強機體抗氧化損傷的能力、預(yù)防動物慢性氧中毒、減輕中樞神經(jīng)系統(tǒng)(central nervous system,CNS)缺血性損傷、提高CNS對HBO的敏感性。同時,我們研究發(fā)現(xiàn),HBO適應(yīng)性暴露可提高機體耐受低氧損傷的能力,但其誘導機制尚不清楚。 一氧化氮(nitric oxide,NO)是一種高生物活性的氣體分子,在體內(nèi)發(fā)揮多種生物學效應(yīng),如神經(jīng)調(diào)節(jié)、舒張血管、細胞再生,尤其是在改善腦血流、神經(jīng)保護方面發(fā)揮重要作用,對腦缺血缺氧具有保護作用。一氧化氮合酶(nitric oxide synthase,NOS)在體內(nèi)可催化精氨酸生成NO和胍氨酸,NOS的含量及活性直接影響體內(nèi)NO的含量。 NOS活性增強,NO生成增多可能通過以下幾種途徑發(fā)揮對缺血缺氧腦組織損傷的保護作用:(1)舒張血管:NO通過與血管平滑肌細胞內(nèi)可溶性鳥苷酸環(huán)化酶(soluble guanylyl cyclase,sGC)結(jié)合,引起細胞內(nèi)環(huán)磷酸鳥苷(cyclic GMP,cGMP)增加并進一步激活其下游信號轉(zhuǎn)導途徑而最終引起血管舒張。同時,NO還能阻止去甲腎上腺素和5-羥色胺等物質(zhì)所引發(fā)的腦動脈收縮反應(yīng)。(2)信息傳遞:腦動脈由非腎上腺素能非膽堿能(NANC)神經(jīng)支配,NANC神經(jīng)末梢釋放的NO在NANC神經(jīng)與腦血管平滑肌之間的信息傳遞中起著重要的作用。(3)維持血管正常結(jié)構(gòu):主要通過抑制血管平滑肌增殖,抑制血小板、白細胞的粘附和聚集,保護腦血管內(nèi)皮而發(fā)揮作用。(4)與低氧誘導因子-1(hypoxia-inducible factor-1,
[Abstract]:Hypoxia is the main pathophysiological response of many diseases such as heart, lung, stroke and tumor. The classical method of inducing hypoxia tolerance is hypoxic preconditioning. Hyperbaric oxygen (HBO) and hypoxic adaptive exposure can enhance the ability of antioxidant injury, prevent chronic oxygen poisoning in animals, alleviate central nervous system central nervous system ischemic damage, and enhance the sensitivity of CNS to HBO. We found that adaptive exposure to HBO can improve the ability of tolerance to hypoxia injury, but the mechanism of its induction is not clear. Nitric oxide nitric oxide (no) is a highly bioactive gas molecule that plays many biological effects in the body, such as nerve regulation, vasodilation, cell regeneration, especially in improving cerebral blood flow and neuroprotection. Nitric oxide synthase (NOS) can catalyze arginine to produce no and guanidine acid. The enhancement of NOS activity and the increase of no production may play a protective role against ischemic and hypoxic brain tissue injury in the following ways: 1) vasodilator 1) vasodilator: no binds to soluble guanylyl cyclase in vascular smooth muscle cells (VSMCs). It also increases and further activates its downstream signal transduction pathway and eventually results in vasodilation. At the same time, no can prevent the contractility of cerebral artery induced by norepinephrine and serotonin, and other substances, such as norepinephrine and serotonin. (2) Information transduction: the cerebral artery innervated by non-adrenergic, non-cholinergic, NANC- (no) released from the nerve endings of the NANCs plays an important role in the transmission of information between the NANC nerve and the vascular smooth muscle. Mainly by inhibiting the proliferation of vascular smooth muscle, Inhibiting the adhesion and aggregation of platelets, leukocytes, and protecting cerebrovascular endothelium. 4) and hypoxia-inducible factor-1, a hypoxia-inducible factor-1, a hypoxia-inducible factor-1, and hypoxia-inducible factor-1.
【學位授予單位】:第二軍醫(yī)大學
【學位級別】:碩士
【學位授予年份】:2006
【分類號】:R363

【參考文獻】

相關(guān)期刊論文 前4條

1 彭兆云;杜晶;孫學軍;陳簫瑩;劉昀;練慶林;蔣春雷;;高壓氧預(yù)處理對小鼠運動耐力的影響[J];第二軍醫(yī)大學學報;2006年01期

2 王偉,張芳,哈振德,張西洲,馬勇,崔建華;藥物對高原人體運動時血氧飽和度的影響[J];高原醫(yī)學雜志;2003年03期

3 劉磊,劉景昌,藺世龍,李斌;NO在高壓氧調(diào)控腦微血管舒縮功能中的效用[J];微循環(huán)學雜志;1999年02期

4 李茁,高春錦,葛環(huán),武連華,侯曉敏;急性一氧化碳中毒大鼠血小板活性的變化及其高壓氧暴露的影響[J];中華航海醫(yī)學與高氣壓醫(yī)學雜志;2005年02期



本文編號:1541468

資料下載
論文發(fā)表

本文鏈接:http://www.wukwdryxk.cn/yixuelunwen/binglixuelunwen/1541468.html


Copyright(c)文論論文網(wǎng)All Rights Reserved | 網(wǎng)站地圖 |

版權(quán)申明:資料由用戶d7621***提供,本站僅收錄摘要或目錄,作者需要刪除請E-mail郵箱bigeng88@qq.com
69成人免费视频无码专区| 美女把尿口扒开让男人玩| 亚洲VA欧美VA国产综合| 精品国产一区二区三区香蕉| 精品无码国产一区二区三区麻豆| 欧美日韩亚洲tv不卡久久| 播播影院| 国产性70yerg老太| 黑人超硬巨大xxxooo| jzzjzzjzz亚洲成孰少妇| 色呦呦国产| 脱丝袜| 91精品91久久久中77777| 久久久国产一区| 久久99精品久久久久久久不卡| 自拍偷自拍亚洲精品被多人伦好爽| 亚洲欧美日韩国产成人| 日韩性色| 欧美一区二区三区久久精品 | 2019年中文字字幕在线看不卡| 国产日韩欧美亚欧在线| 日韩AV片无码一区二区三区不卡| 7777色鬼XXXX欧美色妇| 2020国产精品永久在线| 国产成人一区二区三区在线| 国产亚洲综合久久系列| 久久综合九色综合欧美婷婷| 成人年无码AV片在线观看| 欧洲熟妇色XXXX欧美老妇性| 7777色鬼XXXX欧美色妇| 亚洲码国产精品高潮在线| 国产AV午夜精品一区二区入口| 国产美女露脸口爆吞精| 无码国产精品一区二区免费式芒果 | 亚洲人AV在线无码影院观看| 欧洲熟妇精品视频| 久久夜色精品国产亚洲| 最新国产av无码专区亚洲 | 国内精品视频一区二区三区| 国产v亚洲v欧美v专区| 欧美牲交A欧美牲交AⅤ久久|