本文關(guān)鍵詞：106例青年女性乳腺癌臨床病理特點(diǎn)的回顧性分析，由筆耕文化傳播整理發(fā)布。

106例青年女性乳腺癌臨床病理特點(diǎn)的回顧性分析

Retrospective analysis of clinicopathological characteristics of 106 young women with breast cancer

[1] [2] [3] [4] [5] [6]

TANG Hong-ping, XIE Gui-e, HUANG Li, JIANG Hui, GAO Hui-jun, ZHANG Yan-rui.（ Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Me

[1]南方醫(yī)科大學(xué)附屬深圳婦幼保健院病理科,廣東深圳518028; [2]廣州醫(yī)學(xué)院附屬婦女兒童醫(yī)療中心優(yōu)生圍產(chǎn)研究所,廣州510623

文章摘要：目的回顧性分析青年女性乳腺癌的臨床病理特征，探討其發(fā)病特點(diǎn)，為青年女性乳腺癌臨床診治提供經(jīng)驗(yàn)。方法整理并分析南方醫(yī)科大學(xué)附屬深圳婦幼保健院2007年1月至2012年12月確診的106例青年（≤35歲）女性乳腺癌（青年組）的臨床病理資料及相關(guān)免疫組化指標(biāo)，并與同期診斷的435例年齡〉35歲的中老年女性乳腺癌（中老年組）進(jìn)行對(duì)比分析。計(jì)數(shù)資料間率的比較采用Х^2檢驗(yàn)。結(jié)果青年組乳腺癌占同期收治乳腺癌的19．6％（106／541），病理類型以浸潤性導(dǎo)管癌為主，占86．8％（92／106）。與中老年組比較，其組織學(xué)分級(jí)（Ⅱ／Ⅲ級(jí)）、腋窩淋巴結(jié)轉(zhuǎn)移率和HER-2表達(dá)水平更高[93．4％（99／106）比85．3％（371／435），37．7％（40／106）比26．2％（114／435），，52．8％（56／106）比40．7％（177／435），P值均〈0．050，而ER和PR表達(dá)水平則更低[57．5％（61／106）比68．5％（298／435），60．4％（64／106）比70．3％（306／435），P值均〈0．050]。并且，兩組間腫瘤直徑、病理類型及P53表達(dá)水平的差異均無統(tǒng)計(jì)學(xué)意義（P〉0．050）。結(jié)論青年女性乳腺癌有特殊的臨床病理特征，其組織學(xué)分級(jí)、淋巴結(jié)轉(zhuǎn)移率和HER．2表達(dá)水平高，而ER、PR表達(dá)低，其惡性程度更高，臨床處理需注意早期診斷和合理治療。

Abstr：Objective To retrospectively analyze the clinicopathological characteristics of breast cancer in young women and explore its onset characteristics, so as to provide references for clinical diagnosis and treatment of breast cancer in young female patients. Methods The clinicopathologieal characteristics and the immunohistochemical data of 106 young （ ≤35 years） and 435 elderly （〉35 years） female patients with breast cancer pathologically confirmed in Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University from January 2007 to December 2012 were collected and comparatively analyzed. Chi-square test was used for enumeration data. Results Young patients accounted for 19. 6% （ 106/541 ） of all breast cancer patients treated in the hospital during the same period. Invasive ductal carcinoma was the major pathological type （ 86. 8% , 92/106）. Compared with elderly patients, histological grading （ grade Ⅱ / Ⅲ ） [ 93.4% （ 99/ 106） vs 85.3% （371/435） ], rate of axillary node metastases [37.7% （40/106） vs 26. 2% （114/435） ] and positive rate of HER-2 [ 52. 8% （ 56/106 ） vs 40. 7% （ 177/435 ） ] in young patients were higher, but the positive rates of ER [57.5% （61/106） vs 68. 5% （298/435） ] and PR [60. 4% （64/106） vs 70. 3% （306/ 435 ） ] were lower（ P〈0. 050）. There were no significant differences in tumor size, pathological types and P53 level between these two groups （P〉0. 050 ）. Conclusion Breast cancer in young women has its specific elinicopathological characteristics,including higher histological grade, higher rate of axillary nodes metastases and higher positive rate of HER-2, lower positive rates of ER and PR, and higher degree of malignancy, so the surgeon should pay

文章關(guān)鍵詞：

Keyword：:young adult breast neoplasms clinical pathology immunohistochemistry

課題項(xiàng)目：國家自然科學(xué)基金資助項(xiàng)目（81101682/H1609）

作者信息：會(huì)員可見

  本文關(guān)鍵詞：106例青年女性乳腺癌臨床病理特點(diǎn)的回顧性分析，由筆耕文化傳播整理發(fā)布。