發(fā)布時間：2018-04-04 03:38

  本文選題：循環(huán)內(nèi)皮祖細胞　切入點：經(jīng)皮冠狀動脈介入治療　出處：《中國動脈硬化雜志》2017年02期

【摘要】：目的研究慢性穩(wěn)定型心絞痛患者經(jīng)皮冠狀動脈介入治療(PCI)前后循環(huán)內(nèi)皮祖細胞(EPC)的數(shù)量變化,并探討PCI術后CD34~+/KDR~+最大動員幅度與患者內(nèi)皮損傷定量參數(shù)等臨床資料的相關性。方法選取93例診斷為慢性穩(wěn)定型心絞痛的患者,將其中成功行PCI術治療的72例患者作為PCI組,21例僅行冠狀動脈造影術(CAG)保守治療的患者作為對照組。采集患者股動脈鞘管或肘正中靜脈血樣,通過流式細胞儀對PCI組和對照組患者CAG術后即刻(基線水平)及PCI術后或CAG后1 h、3 h、5 h、7 h、24 h的EPC數(shù)量進行測定。結果不同類型的EPC在不同時間點及在PCI組和對照組兩組間的總體均數(shù)存在統(tǒng)計學差異(P0.05)。PCI組中,與基線水平相比,CD34~+/KDR~+在24 h,CD133-/CD34~+/KDR~+在3 h、5 h、24 h,CD133~+/CD34~+/KDR~+在5 h、7 h,CD133~+/KDR~+在3 h、5 h,CD133~+/CD34~+在24 h差異有統(tǒng)計學意義(P0.05)。對照組中,各類型EPC在不同時間點計數(shù)與基線水平相比,無統(tǒng)計學差異(P0.05)。CD34~+/KDR~+最大動員幅度與C反應蛋白呈現(xiàn)負相關,與體質(zhì)指數(shù)、服用血管緊張素轉化酶抑制劑或血管緊張素Ⅱ受體拮抗劑類藥物的情況、血管內(nèi)皮損傷定量參數(shù)呈現(xiàn)正相關(P0.01)。結論PCI導致的血管內(nèi)皮損傷可以引發(fā)EPC時間依賴性的動態(tài)變化,同時可以促進CD34~+/KDR~+的大幅動員、遷移、歸巢,有利于受損血管內(nèi)皮修復愈合,減少并發(fā)癥,改善患者預后。
[Abstract]:Objective to study the quantitative changes of circulating endothelial progenitor cells (EPC) in patients with chronic stable angina pectoris before and after percutaneous coronary intervention (PCI), and to explore the correlation between the maximum mobilization range of CD34 ~ / KDR~ after PCI and the quantitative parameters of endothelial injury.Methods Ninety-three patients with chronic stable angina pectoris were selected and 72 patients who were successfully treated with PCI were selected as the control group. 21 patients in the PCI group were treated conservatively by coronary angiography.The blood samples of the femoral artery sheath tube or the median elbow vein were collected, and the number of EPC was measured immediately after CAG in PCI group and control group (baseline level) and 24 h after PCI or 1 h after PCI or 5 h and 7 h after CAG by flow cytometry.Results there were significant differences in the total mean of different types of EPC at different time points and between the PCI group and the control group.涓庡熀綰挎按騫崇浉姣，

本文編號：1708200